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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

单词designer 联想记忆:
Apple's brand value rose 5 percent from a year ago to $178 billion and Google's brand value was up 11 percent from a year ago to $133 billion, according to the report.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

But the declines continued, and now it’s all over, red rover.
这些正在修建一座足球场的工人在巴格达东北部什叶派穆斯林聚居的哈比比亚城区被绑架。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

民粹主义的兴起(即使在美国和英国这样的就业人数众多的国家也是如此)使得政客们认识到,就业的质量和数量同等重要。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

In being named CEO, Mary Barra broke through several historical barriers in moving from GM's third-most powerful executive position to its first. Her job was made both easier by the appointment of a non-executive chairman to handle the board of directors, and more difficult by the decision to give her old job to one of her rivals. As the first product engineer to head the company in two decades, she will be deluged with suggestions about everything from air conditioning vents in new pickups to the future of brands like Buick and Chevrolet.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

北京大学和北京外国语大学的2017届毕业生平均月薪分别为9042元和9020元,位居第二、三位。
艾伦非常有才,主持也自然,她知道如何调动世界范围内的观众的心绪。她是奥斯卡的铁杆粉丝,而我们也是她的庞大粉丝团。真是完美的契合。
荷兰危机牵涉到成熟的金融专业人士,那些惯于分析金融和经济趋势的人们。但是,他们过于看重个人经验。
3. Economy is already crashing, GDP will get even worse in 2014-2016

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

贾斯汀·比伯成全美音乐奖最大赢家
“十二五”期间,中国货物出口年均增长6.5%,占全球的份额从2010年的10.4%提升到2015年的13.2%,速度明显快于全球其他主要经济体。而服务贸易年均增长超过13.6%,位居世界第二。
1.你一夜之间成了领英平台的香饽饽。
单词extravagant 联想记忆:

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

镜头切换到《爱乐之城》的演员和剧组人员那里,他们高兴得抱成一团了,但大家可以听到比蒂好像在说:“应该是爱玛?斯通。”而唐纳薇回应道:“什么?”当《爱乐之城》剧组上台领奖时,可以听到旁边的舞台管理人员说:“哦……哦!天啊!他拿错信封了!”

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Two arrests have been made in connection to the shooting death of 14-year-old Lecent Ross, police said Thursday.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

knot
No details have been given about the content of the leaflets, though propaganda sent in the past has denounced North Korea's ruling family.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

In a bid to curb capital outflows and ease downward pressure on the renminbi, Chinese regulators have imposed a series of new restrictions on outbound dealmaking in recent months. The new curbs came after outbound investment in non-financial assets surged by 44 per cent in 2016 to a record $170bn.
"The longer people sit out of the job market, the harder it's going to be for them to re-enter," Frederickson says.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Eleven James:
他们在培养核心球员,寻求合适的角色球员。他们可是湖人队啊,对他们而言,很有可能会有一到两个有实力的自由球员主动投怀送抱。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

这些,都只是纽约人2015年将会遇到的部分问题。而且,邻居家的儿子在圣诞节收到了新的爵士鼓,你又免不了要头疼了……
That growth in the value of inbound shipments came despite a strengthening dollar that drove up costs for importers. Import growth valued in local currency terms reflected that relative weakness with a rise of 13 per cent in November.
Scientists confirmed Monday that a skeleton found under a carpark in the English city of Leicester was that of King Richard III, in a bizarre end to a 500-year-old historical mystery.
中国拒绝承认存在任何不当行为,并表示正在努力解决工业产能过剩的问题。随着中国经济增长放缓,该问题变得日益尖锐。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

节目23 《直通春晚》①《山路十八弯》(表演者:阿普萨萨)②《我是一只小小鸟》(表演者:许艺娜)③《我爱你中国》(表演者:平安)

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

2. How to write a CV
Gross shifts, makes no sense: Just four months ago he warned the Fed is blowing a Credit Supernova, a new monetary bubble that would implode Bernanke's arrogant risky experiment putting America's future at great risk by bankrolling a Wall Street Ponzi Scheme and blowing a huge financial bubble.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

But Moonlight kept pace with it over the course of a marathon four-hour ceremony. Barry Jenkins and Tarell Alvin McCraney won best adapted screenplay, while Mahershala Ali won best supporting actor — the first Oscar for a Muslim American actor.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

触摸屏主要生产商蓝思科技的周群飞以450亿元的资本净值位列榜单第3。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

但行业观察人士说,这样的观点忽略了一个中国在创新方面与西方竞争对手直接对峙的领域:让中国版本更具互动性、使用起来也更有趣的那些额外功能。
19. 前进直至消失。昆汀·塔伦蒂诺(Quentin Trantino)用70毫米胶片拍摄了新片《八恶人》(The Hateful Eight),这部影片将在将近100家影院上映,它们和全国大多数影院一样,通常使用数码放映。不管你对塔伦蒂诺有何看法,你都应该去影院看《八恶人》,这样你就可以自己看看,这个行业被迫转向数码,对电影究竟产生了多大的影响。
plane
《在生前留下的物品中回忆世界上最长寿的人》(Remembering the World’s Oldest Person, in the Objects She Left Behind)

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

[?d.mini'strein]
有些纽约人就像讨厌房东一样讨厌邻居。合作公寓和共管公寓的管委会要小心了:你们也好不到哪去。
报告还显示,2012年以来,企业养老保险累计结余虽不断扩大,但可支付月数由2012年的19.7个月下降至2015年的17.7个月。
Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
['gl?ub?l]

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

The Shanghai Composite is nursing a decline of 6.85 per cent, while the tech-focused Shenzhen Composite is down 8.19 per cent.
n. 决定,决策

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 资本退潮 长租公寓重新洗牌
Critical Review

The role of biosensors in the detection of emerging infectious diseases

London Business School (LBS) performed strongly across all five rankings. All of its programmes are in the European top 10, including its full-time MBAs, ranked second, and its joint EMBA programme (taught with Columbia Business School in the US) and customised executive education courses, both in fourth place.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Promote all-round economic, political, cultural, social, and ecological progress

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

这些排行榜是基于某个特定学科的研究能力而做出评价,与综合榜单评价方式不同。
Song “Embrace Happiness”(Kelly Chen)
Google's top 10 searches for 2017–U.S.
此外,《美国新闻与世界报道》还提供了学科排行榜,包括计算机科学、经济学和商科以及工程学等热门学科。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Lori Steele
但是,海外机构投资者表示,随着中国经济增长放慢,香港房地产市场已经过热,正在进入调整阶段。
“One employee’s parents contacted the company to let us know their son was resigning.
em进入,brace胳膊-拥抱

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

根据这份由互联网薪酬调查及报告提供商中国薪酬网发布的调查显示,清华大学2017届毕业生平均月薪达9065元。
receptive

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Miranda Lambert “Bathroom Sink” (RCA Nashville)
最新的官方资料显示十二月中旬的数据大幅增长,有1200人已经离开或者正谋求去战场加入圣战份子。
Say this about Bank of America chief Brian Moynihan: He certainly knows how to talk the talk. In his letter to shareholders, Moynihan went out of his way to thank U.S. taxpayers for making $45 billion in TARP funds available. He also described how he is working closely with 'policy leaders' on financial reform. Whether he can walk the walk - i.e., turn around BofA's fortunes - is another matter. While the company did repay its TARP loan in December, it is still sitting on billions of dollars of vulnerable residential and commercial mortgage debt - one reason the company spent 8,000 words discussing risk in its annual report.
你肯定知道,那个似乎永远都待在公司的老家伙现在依然不会使用电子邮件。到了2014年,如果你跟不上社交媒体的新潮流,你就跟那个老家伙没什么两样。今年发布于招聘信息搜索引擎Indeed.com的招聘广告,提及社交媒体使用技能的是去年的13倍。Indeed公司传讯总监艾米?克劳今年初接受数字经济新闻网Quartz采访时说:“从人力资源到产品开发,再到客户服务,企业各个部门对精通社交媒体的求职者的需求正在急剧增加。”预计将出现在Twitter和Facebook上的不仅仅是市场、销售和客服等部门,研发、物流和人力资源等差异巨大的团队也越来越多地使用Yammer等内部网络以简化操作流程。事实上,社交媒体已经发展为职场技能的重要一环,就连各大高校现在也纷纷面向不善社交的企业开设认证项目,帮助它们适应日新月异的社交媒体世界。
与亨特相反,在《钢琴课》中与亨特联合主演的安娜·帕奎因(Anna Paquin),她的小金人似乎居无定所,游荡在她装袜子的抽屉和放靴子的地板之间。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

节目35 歌曲《美丽中国》,沙宝亮 徐千雅
The quality of consumer goods imported through channels other than e-commerce proved to be higher, with only 29 percent falling short of standards, according to figures released by the administration.
首先,正如咨询与培训机构RedPrairie公司的供应链专家汤姆?科赞斯基所言,一提到物流行业,多数人都觉得它“没有吸引力”,是一项乏味且薪水不高的仓储工作。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

In short, some New Yorkers dislike their neighbors almost as much as they do their landlords. Co-op and condominium boards beware: You do not fare much better.
All this is happening before our eyes and yet we act as if we have all the time we want and all the solutions. I'm only a child and I don't have all the solutions, but I want you to realise, neither do you! 所有这一切就发生在我们眼前,然而我们还是一直向大自然无度索取我们所需要的。我仅仅是个孩子,我不知道该怎么办。 但我们这些孩子——这个星球的未来需要让您认识到,您不能说没办法!

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 租房分期如何不被骗
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

于上周二发布的《2016胡润IT富豪榜》显示,排在前50名的中国IT富豪的平均财富同比上涨13%,至创纪录的269亿元。
inspection
“即便人们充分了解了(美联储政策的作用),市场动态也可能相对容易地变得不稳定或不利,”他说,“届时你将陷入一个卖盘压力自我强化的循环。”

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

一位新浪微博网友写道:“不敢相信这么多医生都在论文中造假。病人还能相信他们可以帮人治病吗?”
英国《泰晤士高等教育》专刊于上周四公布的一项调查显示,中国内地两所高校入选亚洲大学前三名。
9. Investors brains are so distracted, in denial, they won't get out in time.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

0=false

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

1.哥吃的不是面,是寂寞。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Median GMAT: 700
安娜上班的地方位于富人区的一家购物中心的车库,她抱怨道:“我去上班的路上要多花费一小时,但我却得不到一个现场看球的机会。“

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

At the same time, college graduates' interest in further education has also dwindled, leading to an increase in students wanting employment from 71.2 percent last year to 75.6 percent this year. Nearly 30 percent of those graduates accepted offers from the internet industry, which is among the highest paying.
●“Girl Infects 586 Men With HIV On Purpose, Plans On Infecting 2,000 More Before 2017 - TRENDING”
What growth dollar exports did see among major trading partners came from shipments to the US, which rose 5.5 per cent year on year to $37.06bn. Exports to South Korea also showed growth of 8.3 per cent to $10.2bn.
The Florida Project

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

由美国演员Jared Leto领衔的“火星三十秒”拿到了最佳另类音乐奖,同时还有Lana Del Rey,Lorde,The XX和Imanine Dragons等人提名。
此时可能会有旅客好奇,是否会有一座机场超过备受称赞的樟宜机场呢?

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

日本
参与沙特反腐行动的一名官员称,达成金额据信超过10亿美元的和解协议后,在该国反腐风暴中被捕的地位最高的沙特王室成员之一、米特卜·本·阿卜杜拉王子已获释。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

While Cousins' volatile personality and high-usage tendencies present challenges, there are numerous justifications for rolling the dice:

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

伊利诺伊大学的科学家们上个月取得的突破性进展预示着全球农业将迎来第二次绿色革命——他们提高了光合作用的效率,这是植物将阳光转化为生物量的过程,也是人类所有食物的来源。
《银河护卫队》之所以能成为一部大获成功的超级英雄系列电影,原因之一就是它的幽默感。这部影片充满了自嘲和讽刺。观看这部影片的时候,你不会一直笑个不停,但至少会有一些瞬间让你哈哈大笑,比如树人和克里斯?帕特出场的时候。
1.保险精算师
爱尔兰球迷。他们唱歌,跳舞,喝酒然后再唱歌。波尔多,球迷小伙们正在给一个法国婴儿唱摇篮曲让小孩睡觉。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Get Out
游戏平台:PlayStation 4

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

许多管理者提到了一些极其失礼的情况。求职者:
除了编程和写作业,达洛伊西奥开始抽时间来阅读自然语言处理(natural language processing)方面的文章。他还学习了拉丁文和中文,并且对语言学理念产生了浓厚的兴趣,例如语法框架、语素解析,以及上世纪60年代语言学家理查德?蒙塔古(Richard Montague) 的理论。达洛伊西奥热情地说道,他是我最喜欢的语言学家,根据他的理论,自然语言可以被视作遵照一定句法写出的编程语言。
adj. 易坏的,脆弱的,浅薄的 n. 复写纸,薄纸副本

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 房山红色旅游助推乡村发展
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

根据全球最大航运公司马士基航运公司(Maersk Line)的数据,从汽车到集装箱运输的纺织品,1月中国对巴西出口同比下降60%,而通过集装箱进入拉美最大经济体的总进口量减半。
That is up from a rise of 11.2 per cent in September.
Atlas Wearables founder Peter Li says battery technology and user retention are two more obstacles facing the wearables market. Some use cases require significant improvements to battery technology for a compelling experience, he says, and there’s always a balance to be struck between wear time between charges and processing power and features.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Turkey’s ministers have been rallying Turkish expat communities across Europe to win support for Erdogan-backed constitutional changes, which will be voted on in a referendum next month.
不错,2014年完全是一场灾难,只等着引爆。在《年内股市崩盘的概率有多大?》(Doomsday poll: 87% risk of stock crash by year-end)一文中,我们分析了今年年初以来的10大崩盘征兆。之后,我们又不断发现了更多新的妖魔。它们有如嘀嗒作响的定时炸弹,来自国会、最高法院、性问题、碳排放、石油巨头、国家安全局(NSA)、国税局(IRS)、茶党式财政紧缩。接踵而至,让人无法招架。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

“此种情形中,宪法还真不适用。宪法限制了政府对言论的压制,但不限制私立学校。”
有相当多的学生对英国的签证规定感到失望。“很多人认为该项目是在欧洲就业的一条途径,”一名学员表示,“如果这是他们的目标,那么其中很多人肯定已经失望地离开了。”
岁末来临,二十多部影片轮番上映(hit cinema)。而今年的贺岁片大战随着《龙门飞甲》和《金陵十三钗》的上映而硝烟四起,一场票房PK战也随之拉开帷幕!December is a golde

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

U2乐队主唱波诺、主吉他手"刀刃"和蒂娜·特纳联手合作,共同完成了这首最狂野的007电影主题曲。你会被这首歌的演唱者吸引,并且愿意为她做任何事情。在电影《黄金眼》的主题曲中,蒂娜·特纳在《黄金眼》里面所展现的性感是我们一生都无法企及的。007系列电影主题曲从未如此甜蜜性感,好似歌曲里注入了性激素。
7. An unexpected new lung function has been found. Researchers have found that lungs don't just facilitate respiration - they also play a key role in blood production, with the ability to produce more than 10 million platelets (tiny blood cells) per hour. That equates to the majority of platelets in circulation at any given moment.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

smart
地球大气中的二氧化碳浓度超过了百万分之400个单位
《倒霉蛋:罗伯特·博斯特的生与死》(Jinx: The Life and Deaths of Robert Durst),HBO,2月8日播出。《追捕弗雷德曼家族》(Capturing the Friedmans)的导演安德鲁·杰瑞克奇(Andrew Jarecki)执导了这部六集系列纪录片,在片中与博斯特先生通力合作。博斯特出身纽约房地产世家,与数起谋杀事件有关,他的第一任妻子失踪之谜至今未曾解开。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

在出售给Facebook前,WhatsApp一直特别反对植入广告。该公司首席执行官让o库姆在自己桌上一直贴着联合创始人布莱恩o阿克顿留下的一张便条,随时提醒自己牢记公司的核心价值观:“不要广告!不要游戏!不要宣传噱头!”这样一来,短信应用只好想出别的创意。比如Tango就在用户的短信“收件箱”里插入广告。中国互联网巨头腾讯公司旗下的短信应用——微信,则通过游戏、贴纸(类似于表情符号)和移动购物等方式谋取赚钱之道。Kik则提供一种被一些人称为“聊天广告”的功能,用户通过它能和幽默网站Funny or Die及电影信息网站Moviefone这类品牌运营的聊天程序进行交谈。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

就算油价在2015年有可能反弹,但是油价几乎不可能再短期内回到100美元一桶,除非在世界主要产油地区发生广泛的地缘政治危机。所以这份礼物将在2015年得到持续并且长久的促进美国经济的加快复苏。
vt. 鼓励,促进,支持

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

My arms are wide open for you this New Year.我张开双臂,盼与你共度新春佳节。
We learned about the causes and consequences of rising obesity around the world.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 迎接2.0时代绿建行业整装待发
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

a
7) Let Me Play Devil’s Advocate: Looking for a subtle way to critique? Turn the conversation into an exercise where you’re a detached party performing a function: Poking holes in the logic and plan of attack. You use this strategy to stress test ideas without making the process personal.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Unfortunately for May, the big drop in the pound since the Brexit vote means her salary has plunged in dollar terms.
信息技术是第三大行业,有18个入围品牌。上榜IT品牌的总价值占到了榜单的22.5%.平均价值上升了10%。北京是IT行业总部的首选位置,有12个上榜IT品牌的总部设在这里。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

virus

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Amazon, Starbucks and Facebook have seen their brand values shoot up in 2016 compared with 2015. Amazon’s 59 per cent rise in value to $99bn and seventh place ranking, is partly due to its ability to create demand and not just satisfy it, according to Elspeth Cheung, head of BrandZ valuation at Millward Brown. She says Amazon’s one-hour delivery service has put pressure on other retailers to speed up delivery times while the online retailer’s move into logistics poses a threat to courier services UPS, FedEx and DHL.
在考辛斯被交易后,接近一半国王队名单上的球员都应被清洗,然而并没有。很好。带上Buddy Mania,球馆里还有很多空座位可以挑选。
Don't Make Yourself Too Comfortable
3. Tablets meet viruses.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

9.触屏

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Despite car and truck sales that motored past 16 million for the first time since 2007, recalls dominated the news for most of the year. General Motors GM 1.42% held center stage, dealing with cascading revelations about faulty ignition switches and recalling millions of vehicles. While GM opted for something approaching full disclosure of its missteps , publishing an report into company-wide fumbles, Japanese airbag maker Tanaka chose to stonewall. It left any remedies up to its beleaguered customers, notably Honda and Toyota. They are the ones who deal with the fallout of exploding safety devices that fatally fired shrapnel throughout the passenger compartment.
retreat
Autonomous cars: Researchers are working on devices that will automatically park your car in a parking lot without you being in, or near, the car. It will also slip a note under the wipers of the car next to it with your phone number and insurance carrier in case of any scratches.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

For those outside the scientific community, the response to the retraction has been mixed.
You'd probably never think that a belt could be integrated with artificial intelligence, yet Belty managed to do it and make it seem stylish. The Beltyautomatically makes you think, "why do I need this?" Then your second thought will probably be, "what if it's hacked and they make it so tight I can't breathe?" The first question is rational; the second one is far-fetched — but if it makes you think twice about buying this product, that's not a bad thing.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

施密特在接受采访时问道,“为什么我们接连看到如此多的创纪录温暖年度?这是因为地球正在变暖。根本的问题是,这是一种长期趋势,这种趋势不会消失。”
vt. 忽视,疏忽,忽略

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

31岁的扎克伯格去年的表现力压群豪,个人资产上涨了112亿美元,从去年的第十六位跃升至今年的第六位。这是他和杰夫·贝佐斯首次进入福布斯年度排名榜单前十位。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

"Poverty has stunted further growth in Internet users, which has kept the Net user population to around 50 percent," Li said.
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA,简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜,也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
其他上榜的明星还有:凯特王妃(排名第八),泰勒·斯威夫特(第12名),金·卡戴珊(第38名),和索菲娅·维加拉(第100名)。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

卡恩在宣布收购交易的博客文章中表示,尽管移动设备在改变我们的日常生活,但“大多数文章和网页的格式是为PC端设计,适合用鼠标点击浏览。在手机或平板电脑上浏览它们可能构成重大难题——读者希望更方便地找到对自己重要的内容。”
Americans are celebrating Columbus Day Monday.Columbus Day is a federal holiday observed on the second Monday in October, marking the anniversary of the arrival of Christopher Columbus to the Americas. Columbus, an Italian explorer sailing under the Spanish flag, led four expeditions to the New World, but never accomplished his original goal -- to find a western ocean route to Asia. Instead, Columbus ushered in a new era in world history by opening up the Americas to exploration.
巴韦贾同意这一结论,他指出,韩国和另一个大宗商品净进口国印度,都是成品油的出口国。以美元计算,这些成品油的价值今年应会上升。
Countrywide, month-on-month prices rose in 59 out of 70 cities last month – down from 62 – were unchanged in four and fell in eleven. Cities where prices fell from the previous month included Shenzhen (down 0.3 per cent), Hangzhou (down 0.4 per cent) and Xiamen (down 0.2 per cent).

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Brian Kendrella, president of New York-based Stack's Bowers Galleries, says the auction drew half a dozen bidders from six countries. The winning bidder Thursday was an individual collector from Asia who asked to remain anonymous.
创造一个学习空间

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

我曾被一位CEO要求雇用一位有着乌黑长发的长腿美眉,虽然她的能力不强。还有一次,我被要求不要雇用有小孩的应聘者,因为公司已经雇用了太多为了看足球赛请假的员工。这种事经常发生。
Luckily, the singles are only half the story with Reputation. On "Dress," she's high on the rush of a new romantic thrill; on "New Year's Day," she's trying to figure out what she has after the party's over.
韦斯·安德森(Wes Anderson)的每部电影似乎都存在于它自己的世界里。《布达佩斯大饭店》(The Grand Budapest Hotel)以20世纪30年代为背景,通过独特的元素和道具定义它的世界。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

《今日美国》(USA Today)说,对大多数城市来讲,就业复苏即使能实现,也得是在好几年过后。浏览知名分析师梅瑞迪斯?惠特尼(Meredith Whitney)新书《州的命运》(The Fate of States)时你会看到,她提醒说,“过多的养老金会挤出教育支出等自由派目标,也会挤出保守派希望实现的减税目标”。
在解释他如何改动小说时,赫洛维兹说:“我想答案是在书中忠实于邦德的全部特征。”

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