Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Apple's brand value rose 5 percent from a year ago to $178 billion and Google's brand value was up 11 percent from a year ago to $133 billion, according to the report.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
But the declines continued, and now it’s all over, red rover.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
In being named CEO, Mary Barra broke through several historical barriers in moving from GM's third-most powerful executive position to its first. Her job was made both easier by the appointment of a non-executive chairman to handle the board of directors, and more difficult by the decision to give her old job to one of her rivals. As the first product engineer to head the company in two decades, she will be deluged with suggestions about everything from air conditioning vents in new pickups to the future of brands like Buick and Chevrolet.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
3. Economy is already crashing, GDP will get even worse in 2014-2016
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Two arrests have been made in connection to the shooting death of 14-year-old Lecent Ross, police said Thursday.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
No details have been given about the content of the leaflets, though propaganda sent in the past has denounced North Korea's ruling family.
ACE2 as a potential therapeutic target for pandemic COVID-19
In a bid to curb capital outflows and ease downward pressure on the renminbi, Chinese regulators have imposed a series of new restrictions on outbound dealmaking in recent months. The new curbs came after outbound investment in non-financial assets surged by 44 per cent in 2016 to a record $170bn.
"The longer people sit out of the job market, the harder it's going to be for them to re-enter," Frederickson says.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
That growth in the value of inbound shipments came despite a strengthening dollar that drove up costs for importers. Import growth valued in local currency terms reflected that relative weakness with a rise of 13 per cent in November.
Scientists confirmed Monday that a skeleton found under a carpark in the English city of Leicester was that of King Richard III, in a bizarre end to a 500-year-old historical mystery.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
2. How to write a CV
Gross shifts, makes no sense: Just four months ago he warned the Fed is blowing a Credit Supernova, a new monetary bubble that would implode Bernanke's arrogant risky experiment putting America's future at great risk by bankrolling a Wall Street Ponzi Scheme and blowing a huge financial bubble.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
But Moonlight kept pace with it over the course of a marathon four-hour ceremony. Barry Jenkins and Tarell Alvin McCraney won best adapted screenplay, while Mahershala Ali won best supporting actor — the first Oscar for a Muslim American actor.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
19. 前进直至消失。昆汀·塔伦蒂诺(Quentin Trantino)用70毫米胶片拍摄了新片《八恶人》(The Hateful Eight)，这部影片将在将近100家影院上映，它们和全国大多数影院一样，通常使用数码放映。不管你对塔伦蒂诺有何看法，你都应该去影院看《八恶人》，这样你就可以自己看看，这个行业被迫转向数码，对电影究竟产生了多大的影响。
《在生前留下的物品中回忆世界上最长寿的人》(Remembering the World’s Oldest Person, in the Objects She Left Behind)
Influenza neuraminidase: A druggable target for natural products
Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The Shanghai Composite is nursing a decline of 6.85 per cent, while the tech-focused Shenzhen Composite is down 8.19 per cent.
The role of biosensors in the detection of emerging infectious diseases
London Business School (LBS) performed strongly across all five rankings. All of its programmes are in the European top 10, including its full-time MBAs, ranked second, and its joint EMBA programme (taught with Columbia Business School in the US) and customised executive education courses, both in fourth place.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Promote all-round economic, political, cultural, social, and ecological progress
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Song “Embrace Happiness”(Kelly Chen)
Google's top 10 searches for 2017–U.S.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
“One employee’s parents contacted the company to let us know their son was resigning.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Miranda Lambert “Bathroom Sink” (RCA Nashville)
Say this about Bank of America chief Brian Moynihan: He certainly knows how to talk the talk. In his letter to shareholders, Moynihan went out of his way to thank U.S. taxpayers for making $45 billion in TARP funds available. He also described how he is working closely with 'policy leaders' on financial reform. Whether he can walk the walk - i.e., turn around BofA's fortunes - is another matter. While the company did repay its TARP loan in December, it is still sitting on billions of dollars of vulnerable residential and commercial mortgage debt - one reason the company spent 8,000 words discussing risk in its annual report.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
节目35 歌曲《美丽中国》，沙宝亮 徐千雅
The quality of consumer goods imported through channels other than e-commerce proved to be higher, with only 29 percent falling short of standards, according to figures released by the administration.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
In short, some New Yorkers dislike their neighbors almost as much as they do their landlords. Co-op and condominium boards beware: You do not fare much better.
All this is happening before our eyes and yet we act as if we have all the time we want and all the solutions. I'm only a child and I don't have all the solutions, but I want you to realise, neither do you! 所有这一切就发生在我们眼前，然而我们还是一直向大自然无度索取我们所需要的。我仅仅是个孩子，我不知道该怎么办。 但我们这些孩子——这个星球的未来需要让您认识到，您不能说没办法！
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
9. Investors brains are so distracted, in denial, they won't get out in time.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Median GMAT: 700
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
At the same time, college graduates' interest in further education has also dwindled, leading to an increase in students wanting employment from 71.2 percent last year to 75.6 percent this year. Nearly 30 percent of those graduates accepted offers from the internet industry, which is among the highest paying.
●“Girl Infects 586 Men With HIV On Purpose, Plans On Infecting 2,000 More Before 2017 - TRENDING”
What growth dollar exports did see among major trading partners came from shipments to the US, which rose 5.5 per cent year on year to $37.06bn. Exports to South Korea also showed growth of 8.3 per cent to $10.2bn.
The Florida Project
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
由美国演员Jared Leto领衔的“火星三十秒”拿到了最佳另类音乐奖，同时还有Lana Del Rey，Lorde，The XX和Imanine Dragons等人提名。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
While Cousins' volatile personality and high-usage tendencies present challenges, there are numerous justifications for rolling the dice:
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
除了编程和写作业，达洛伊西奥开始抽时间来阅读自然语言处理(natural language processing)方面的文章。他还学习了拉丁文和中文，并且对语言学理念产生了浓厚的兴趣，例如语法框架、语素解析，以及上世纪60年代语言学家理查德?蒙塔古(Richard Montague) 的理论。达洛伊西奥热情地说道，他是我最喜欢的语言学家，根据他的理论，自然语言可以被视作遵照一定句法写出的编程语言。
adj. 易坏的，脆弱的，浅薄的 n. 复写纸，薄纸副本
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
That is up from a rise of 11.2 per cent in September.
Atlas Wearables founder Peter Li says battery technology and user retention are two more obstacles facing the wearables market. Some use cases require significant improvements to battery technology for a compelling experience, he says, and there’s always a balance to be struck between wear time between charges and processing power and features.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Turkey’s ministers have been rallying Turkish expat communities across Europe to win support for Erdogan-backed constitutional changes, which will be voted on in a referendum next month.
不错，2014年完全是一场灾难，只等着引爆。在《年内股市崩盘的概率有多大？》(Doomsday poll: 87% risk of stock crash by year-end)一文中，我们分析了今年年初以来的10大崩盘征兆。之后，我们又不断发现了更多新的妖魔。它们有如嘀嗒作响的定时炸弹，来自国会、最高法院、性问题、碳排放、石油巨头、国家安全局(NSA)、国税局(IRS)、茶党式财政紧缩。接踵而至，让人无法招架。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
岁末来临，二十多部影片轮番上映(hit cinema)。而今年的贺岁片大战随着《龙门飞甲》和《金陵十三钗》的上映而硝烟四起，一场票房PK战也随之拉开帷幕！December is a golde
A modular microarray imaging system for highly specific COVID-19 antibody testing
7. An unexpected new lung function has been found. Researchers have found that lungs don't just facilitate respiration - they also play a key role in blood production, with the ability to produce more than 10 million platelets (tiny blood cells) per hour. That equates to the majority of platelets in circulation at any given moment.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
《倒霉蛋：罗伯特·博斯特的生与死》(Jinx: The Life and Deaths of Robert Durst)，HBO，2月8日播出。《追捕弗雷德曼家族》(Capturing the Friedmans)的导演安德鲁·杰瑞克奇(Andrew Jarecki)执导了这部六集系列纪录片，在片中与博斯特先生通力合作。博斯特出身纽约房地产世家，与数起谋杀事件有关，他的第一任妻子失踪之谜至今未曾解开。
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
在出售给Facebook前，WhatsApp一直特别反对植入广告。该公司首席执行官让o库姆在自己桌上一直贴着联合创始人布莱恩o阿克顿留下的一张便条，随时提醒自己牢记公司的核心价值观：“不要广告！不要游戏！不要宣传噱头！”这样一来，短信应用只好想出别的创意。比如Tango就在用户的短信“收件箱”里插入广告。中国互联网巨头腾讯公司旗下的短信应用——微信，则通过游戏、贴纸（类似于表情符号）和移动购物等方式谋取赚钱之道。Kik则提供一种被一些人称为“聊天广告”的功能，用户通过它能和幽默网站Funny or Die及电影信息网站Moviefone这类品牌运营的聊天程序进行交谈。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
My arms are wide open for you this New Year.我张开双臂，盼与你共度新春佳节。
We learned about the causes and consequences of rising obesity around the world.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
7) Let Me Play Devil’s Advocate: Looking for a subtle way to critique? Turn the conversation into an exercise where you’re a detached party performing a function: Poking holes in the logic and plan of attack. You use this strategy to stress test ideas without making the process personal.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Unfortunately for May, the big drop in the pound since the Brexit vote means her salary has plunged in dollar terms.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Amazon, Starbucks and Facebook have seen their brand values shoot up in 2016 compared with 2015. Amazon’s 59 per cent rise in value to $99bn and seventh place ranking, is partly due to its ability to create demand and not just satisfy it, according to Elspeth Cheung, head of BrandZ valuation at Millward Brown. She says Amazon’s one-hour delivery service has put pressure on other retailers to speed up delivery times while the online retailer’s move into logistics poses a threat to courier services UPS, FedEx and DHL.
Don't Make Yourself Too Comfortable
3. Tablets meet viruses.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Despite car and truck sales that motored past 16 million for the first time since 2007, recalls dominated the news for most of the year. General Motors GM 1.42% held center stage, dealing with cascading revelations about faulty ignition switches and recalling millions of vehicles. While GM opted for something approaching full disclosure of its missteps , publishing an report into company-wide fumbles, Japanese airbag maker Tanaka chose to stonewall. It left any remedies up to its beleaguered customers, notably Honda and Toyota. They are the ones who deal with the fallout of exploding safety devices that fatally fired shrapnel throughout the passenger compartment.
Autonomous cars: Researchers are working on devices that will automatically park your car in a parking lot without you being in, or near, the car. It will also slip a note under the wipers of the car next to it with your phone number and insurance carrier in case of any scratches.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
For those outside the scientific community, the response to the retraction has been mixed.
You'd probably never think that a belt could be integrated with artificial intelligence, yet Belty managed to do it and make it seem stylish. The Beltyautomatically makes you think, "why do I need this?" Then your second thought will probably be, "what if it's hacked and they make it so tight I can't breathe?" The first question is rational; the second one is far-fetched — but if it makes you think twice about buying this product, that's not a bad thing.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
"Poverty has stunted further growth in Internet users, which has kept the Net user population to around 50 percent," Li said.
2015年英国《金融时报》全球高管工商管理硕士课程(Global Executive MBA，简称全球EMBA)排行榜由于两个原因而引人注目。不仅因为这是英国《金融时报》发布的第100个商学院排行榜，也是因为今年首次有一个主办方包含一所中国内地商学院的项目拔得头筹。
Length-scale dependence of protein hydration-shell density
Americans are celebrating Columbus Day Monday.Columbus Day is a federal holiday observed on the second Monday in October, marking the anniversary of the arrival of Christopher Columbus to the Americas. Columbus, an Italian explorer sailing under the Spanish flag, led four expeditions to the New World, but never accomplished his original goal -- to find a western ocean route to Asia. Instead, Columbus ushered in a new era in world history by opening up the Americas to exploration.
Countrywide, month-on-month prices rose in 59 out of 70 cities last month – down from 62 – were unchanged in four and fell in eleven. Cities where prices fell from the previous month included Shenzhen (down 0.3 per cent), Hangzhou (down 0.4 per cent) and Xiamen (down 0.2 per cent).
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Brian Kendrella, president of New York-based Stack's Bowers Galleries, says the auction drew half a dozen bidders from six countries. The winning bidder Thursday was an individual collector from Asia who asked to remain anonymous.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Luckily, the singles are only half the story with Reputation. On "Dress," she's high on the rush of a new romantic thrill; on "New Year's Day," she's trying to figure out what she has after the party's over.
韦斯·安德森(Wes Anderson)的每部电影似乎都存在于它自己的世界里。《布达佩斯大饭店》(The Grand Budapest Hotel)以20世纪30年代为背景，通过独特的元素和道具定义它的世界。
About this collection
《今日美国》(USA Today)说，对大多数城市来讲，就业复苏即使能实现，也得是在好几年过后。浏览知名分析师梅瑞迪斯?惠特尼(Meredith Whitney)新书《州的命运》(The Fate of States)时你会看到，她提醒说，“过多的养老金会挤出教育支出等自由派目标，也会挤出保守派希望实现的减税目标”。